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Objective To investigate the effect of different treatment methods on the survival of patients with stage Ⅳ differentiated thyroid cancer (DTC).Methods From January 2013 to June 2015,90 patients with stage Ⅳ DTC in the Second Hospital of Shanxi Medical University were randomly divided into three groups according to the digital table,A,B and C group,with 30 cases in each group.The patients in A group were treated with surgery combined with 131 I,and the patients in B group were treated with surgery combined with TSH inhibition,and the patients in C group were treated with operation combined with 131I + TSH inhibition.The therapeutic effect,postoperative quality of life score and short-term and long-term survival rate were evaluated.Results After treatment,the levels of Tg in A group [(25.06 ± 3.41)μg/L] and C group [(24.89 ± 3.27)μg/L] were significantly lower than that in B group [(45.46 ± 3.58) μg/L],and the levels of TSH in B group [(0.36 ± 0.26) mU/L] and C group [(0.36 ± 0.18)mU/L] were significantly lower than that in A group [(0.67 ± 0.31)mU/L] (t =3.624,3.337,3.289,3.667,all P ＜0.05).The success rates of nail clearance in A group and C group were 50.00％ (15/30) and 56.67％ (17/30),respectively,which were significantly higher than 33.33％ (10/30) in B group (x2 =3.475,4.967,all P ＜ 0.05).The postoperative quality of life (GQOL[-74) scores among the three groups had statistically significant differences (F =4.354,5.216,4.672,5.197,all P ＜ 0.05).The 1-year (80.00％),2-year (53.33％) and 3-year (33.33％) survival rates in C group were significantly higher than those in A group (43.33％,36.67％,20.00％) and B group (40.00％,33.33％,16.67％) (x2 =5.467,3.661,3.287,all P ＜0.05).Conclusion For patients with stage Ⅳ DTC,the combination of 131I + TSH inhibitory regimen and operation regimen can significantly improve the therapeutic effect,improve the quality of life and prolong the survival time.
ABSTRACT
Objective@#To investigate the effect of different treatment methods on the survival of patients with stage IV differentiated thyroid cancer (DTC).@*Methods@#From January 2013 to June 2015, 90 patients with stage IV DTC in the Second Hospital of Shanxi Medical University were randomly divided into three groups according to the digital table, A, B and C group, with 30 cases in each group.The patients in A group were treated with surgery combined with 131I, and the patients in B group were treated with surgery combined with TSH inhibition, and the patients in C group were treated with operation combined with 131I + TSH inhibition.The therapeutic effect, postoperative quality of life score and short-term and long-term survival rate were evaluated.@*Results@#After treatment, the levels of Tg in A group [(25.06±3.41)μg/L] and C group [(24.89±3.27)μg/L] were significantly lower than that in B group [(45.46±3.58)μg/L], and the levels of TSH in B group [(0.36±0.26)mU/L] and C group [(0.36±0.18)mU/L] were significantly lower than that in A group [(0.67±0.31)mU/L] (t=3.624, 3.337, 3.289, 3.667, all P<0.05). The success rates of nail clearance in A group and C group were 50.00%(15/30) and 56.67%(17/30), respectively, which were significantly higher than 33.33% (10/30) in B group (χ2=3.475, 4.967, all P<0.05). The postoperative quality of life (GQOLI-74) scores among the three groups had statistically significant differences (F=4.354, 5.216, 4.672, 5.197, all P<0.05). The 1-year (80.00%), 2-year (53.33%) and 3-year (33.33%) survival rates in C group were significantly higher than those in A group (43.33%, 36.67%, 20.00%) and B group (40.00%, 33.33%, 16.67%) (χ2=5.467, 3.661, 3.287, all P<0.05).@*Conclusion@#For patients with stage IV DTC, the combination of 131I+ TSH inhibitory regimen and operation regimen can significantly improve the therapeutic effect, improve the quality of life and prolong the survival time.
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The process of axonal injury after ischemic stroke can be roughly divided into three stages. Each stage has its different temporal and spatial pattern, as well as unique molecular cascade reactions. The process of axonal injury is also related to ischemic stroke subtype, and the treatment must be adjusted accordingly. Axon-glial intercellular neurotransmitter-energy metabolism coupling disorder and Ca2 + overload-mediated apoptosis-like degeneration are the main mechanisms of early axonal injury after stroke. Axonal regeneration and remyelination of damaged axons after stroke play an important role for the recovery of neurological function. Elucidating the axonal injury and repair mechanism after stroke can provide a new strategy for stroke treatment.
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Objective To explore the cultivated methods of dendritic cells (DC) and the killing effect of DC stimulated by CpG ODN1826 on gastritic cancer cells MKN45 in vitro. Methods DC was induced from peripheral blood monocytes stimulated by A group ( GM- CSF + IL-4 ), B group ( GM- CSF + IL-4 + TNF- α), C group(nonCpG ODN) and D group( CpG ODN 1826). The surface markers of DC was analyzed via flow cytometry, and the abilities to stimulate proliferation of allogenic lymphocyte by DC and antitumor experiment were detected by MTT assay. Results On day 10, a majority of cells showed typical morphology of DC in D group and B group with visible branching-like and pseudopod-like structures under microscope. The results of flow cytometry showed that there are significantly high expressed co-stimulated molecules such as CD40, CD1a,CD80, CD86 and MHC- Ⅱ in D group compared to other experimental groups ( P ＜ 0.05 ), which dramatically stimulate the proliferation of allogenic lymphocytes and enhance the killing activity of DC on gastric cancer cells. Conclusion This method can acquire relatively high purified DC, and CpG ODN can significantly induce the differentiation and maturation of DC isolated from peripheral blood and enhance the killing activity of DC on MKN45 by stimulating PBMC in vitro.